Subcutaneous Panniculitis in Sickle Cell Disease (SCD): A Rare Disease Complication

Objective: To delineate the explore potential etiological contributions to subcutaneous panniculitis-like T-cell lymphoma (SPTCL) in adults with sickle cell disease. Sickle cell disease (SCD) is an inherited hematologic disorder where standard treatment may enhance risk of the development of rare comorbidities like SPTCL. Methods: We reviewed the scientific literature and only found one case report detailing the development of SPTCL in an adult with SCD. Results: We reviewed 1 case reports and the general literature on hematolymphoid disorders. We discovered that there are several potential mechanisms to explain SPTCL in SCD but no conclusive evidence to support either. We reported radiographic, serological, immune, and hematological finding from the previous case. Conclusions: SPTCL is a complex disorder with a likely multifactoral etiology. The development of the disease in adults with SCD is rare but possible as evidenced by a published case report. We advocate for additional attention to the intersection of these two diseases for the purpose of better understanding their etiology and epidemiology. More research is needed.