Davide Benedetto Tiz, Francesca Mangiavacchi, L. Sancineto
2026.1.1PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
tlooto Summary
This review provides a comprehensive analysis of the role of nitrile groups in drug design, their pharmacological significance, and the key synthetic strategies used for the development of the eleven FDA-approved nitrile-containing drugs from 2021 to 2024.
Abstract
Abstract Nitrile-containing drugs represent an important class of natural and pharmaceutical compounds, exhibiting diverse biological activities across multiple therapeutic areas. The incorporation of a nitrile functional group in drug molecules influences their pharmacokinetic properties, bioavailability, and metabolic stability. This review provides a comprehensive analysis of the role of nitrile groups in drug design, their pharmacological significance, and the key synthetic strategies used for the development of the eleven FDA-approved nitrile-containing drugs from 2021 to 2024. Graphical abstract
Citation format
TIZ, Davide Benedetto; MANGIAVACCHI, Francesca; SANCINETO, L. The importance of nitrile functionality: FDA-approved small molecules from 2021 to 2024. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2026, 201(4): 376–394.