Ian M Mbano, Nuo Liu, M. Wadsworth, Mark J Chambers, T. Mpotje, O. Asowata, Sarah K Nyquist, Kievershen Nargan, D. Ramsuran, F. Karim, Travis K Hughes, Joshua D. Bromley, Robert Krause, T. Naidoo, L. Tezera, Michaela T. Reichmann, S. K. Ganchua, Henrik N Kløverpris, Kaylesh J Dullabh, R. Madansein, Sergio Triana, A. Steyn, Bonnie Berger, Mohlopheni J. Marakalala, Sarah M. Fortune, JoAnne L. Flynn, Paul T. Elkington, A. Shalek, A. Leslie
2026.1.5JOURNAL OF EXPERIMENTAL MEDICINE
Resumen
Single-cell and spatial transcriptomics of human TB lung tissues from individuals in South Africa revealed that MMP1+CXCL5+ fibroblasts and SPP1+ macrophages are linked to TB disease and TB lung granuloma, uncovering targetable cellular cross talk underlying TB immunopathology and potential avenues for host-directed therapies.
Formato de cita
MBANO, Ian M, et al. Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology. JOURNAL OF EXPERIMENTAL MEDICINE, 2026, 223(3).