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Engineered nanobodies facilitate cryo-EM studies of small proteins

Gangshun Yi, Dimitrios Mamalis

2026.1.7NATURE REVIEWS MOLECULAR CELL BIOLOGY

DOI: 10.1038/s41580-025-00940-2

tlooto Summary

The development of Di-Gembodies, innovative constructs designed to overcome key challenges in applying cryo-electron microscopy to small proteins that are otherwise difficult to resolve are discussed.

Abstract

In this Tools of the Trade article, Yi and Mamalis (Gilbert and Davis labs) discuss the development of Di-Gembodies, innovative constructs designed to overcome key challenges in applying cryo-electron microscopy to small proteins that are otherwise difficult to resolve.

Citation format

YI, Gangshun; MAMALIS, Dimitrios. Engineered nanobodies facilitate cryo-em studies of small proteins. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2026, 27(3): 174–174.