Click Chemistry and ApplicationsCarbohydrate Chemistry and SynthesisChemical Synthesis and Analysis
Saloomeh Maleki, M. Bakherad, H. Nasr‐Isfahani
2026.1.5Journal of Sulfur Chemistry
Abstract
An efficient synthesis of propargyl pyrimidines connected with glucose/galactose moiety by triazole linker through Cu-catalyzed has been developed. The reaction of azido sugar derivatives (β-D-glucopyranose tetraacetate or β-D-galactopyranose tetraacetate) with propargylthio pyrimidines in the presence of CuSO4.5H2O and sodium ascorbate in THF/Isopropanol gave desired glycosyl 1,2,3-triazoles-linked pyrimidines with 81–97% yields. GRAPHICAL ABSTRACT
Citation format
MALEKI, Saloomeh; BAKHERAD, M.; NASR‐ISFAHANI, H. Synthesis of new glycoconjugates by click reaction of β-glycosyl azides and pyrimidines. Journal of Sulfur Chemistry, 2026, 47(2): 210–222.