Possible Link between Sitagliptin and Gynecomastia: A Case Study

In this case report, we present the case of a 69-year-old man with type II diabetes who developed gynecomastia after taking sitagliptin as antidiabetic treatment. A 69-year-old man with type II diabetes mellitus, who had been receiving a com-bination tablet containing sitagliptin 50 mg and metformin 1000 mg twice daily as antidiabetic ther-apy, developed breast enlargement after two months of treatment. No gynecomastia was reported during pretreatment or post-treatment observation. Furthermore, he did not take drugs causing gyne-comastia; he intended to stop this treatment and switch to another one. According to the report, gynecomastia in this patient may be related to the use of sitagliptin. Further studies are important to ensure this effect.