Menghan Lv, Hanxi Yi, Yalan Liu, Yehua Xie, Zeneng Cheng, Feifan Xie, Sanwang Li
tlooto Summary
It is demonstrated that combinations of polymyxin B with tigecycline, imipenem, ceftazidime, or cefepime show promising therapeutic potential against KPC-producing CRKP.
Abstract
Objective: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections often necessitate combination therapy, yet effective treatment options remain limited. This study aimed to evaluate the bactericidal effects of polymyxin B–based combination therapy with ten representative antibiotics against KPC-producing CRKP
Citation format
LV, Menghan, et al. In vitro screening for synergistic polymyxin b-based combinations against KPC- producing carbapenem-resistant klebsiella pneumoniae. Drug Design Development and Therapy, 2026, 20: 1–12.