L. V. Neumerzhytska, D. Kurinnyi, V. Talko, M. H. Romanenko
tlooto Summary
The search results confirm the feasibility of studying the radiationinduced effect at the cytogenetic, genomic and epigenomic levels, which will contribute to solving an important problem in radiobiology, radiation genetics and radiation protection to improve methods for assessing, predicting and preventing the negative effects of radiation on human health.
Abstract
The review highlights current ideas about the mechanisms of radiationinduced genome instability formation.Based on the results of a search in the abstract medical and biological database PubMed/MEDLINE, Google Scholarand a manual search of relevant information sources, data on the use of some cytogenetic and molecular geneticmethods as biomarkers of the effects of lowdose acute and prolonged radiation are analyzed and summarized. Theeffectiveness of the use of natural radioprotectors under various radiation conditions (emergency, professional,radiotherapy, etc.) is considered. The search results confirm the feasibility of studying the radiationinduced effectat the cytogenetic, genomic and epigenomic levels, which will contribute to solving an important problem in radiobiology, radiation genetics and radiation protection to improve methods for assessing, predicting and preventing thenegative effects of radiation on human health.
Citation format
NEUMERZHYTSKA, L. V., et al. BIOMARKERS OF RADIATIONINDUCED GENOMIC INSTABILITY IN SOMATIC CELLS. Problemy Radiatsiinoi Medytsyny ta Radiobiolohii, 2025, 30: 105–125.