Xiaoxia Zhang, Min Quan, Z. Zong, Xiaohui Wang
2026.1.1ANAEROBE
tlooto Summary
Compared with vancomycin, UDCA significantly impedes biofilm formation and bacterial adherence at subinhibitory concentrations, which may be the therapeutic advantages of UDCA and support this old drug to be further developed for CDI prevention.
Abstract
UDCA exhibits limited direct bacteriostatic activity against Clostridioides difficile with a high MIC90 of >128 μg/mL against 121 clinical strains. However, compared with vancomycin, UDCA significantly impedes biofilm formation and bacterial adherence at subinhibitory concentrations, which may be the therapeutic advantages of UDCA and support this old drug to be further developed for CDI prevention.
Citation format
ZHANG, Xiaoxia, et al. Ursodeoxycholic acid inhibits biofilm formation and bacterial adhesion of clostridioides difficile. ANAEROBE, 2026, 98: 103023.