MedicineBiology

K. Ohi, D. Fujikane, Kentaro Takai, A. Kuramitsu, Yukimasa Muto, S. Sugiyama, T. Shioiri

2026.1.24BIPOLAR DISORDERS

DOI: 10.1111/bdi.70078

tlooto Summary

This study aimed to investigate whether methylation risk scores (MRSs) derived from epigenome‐wide association studies for BD risk in living peripheral blood and postmortem hippocampal tissues are associated with BD diagnosis across tissues.

Abstract

Bipolar disorder (BD) is a common psychiatric disorder with complex genetic and epigenetic underpinnings. This study aimed to investigate whether methylation risk scores (MRSs) derived from epigenome‐wide association studies (EWASs) for BD risk in living peripheral blood and postmortem hippocampal tissues are associated with BD diagnosis across tissues.

Citation format

OHI, K., et al. Trans‐tissue effects of hippocampus‐ and blood‐derived DNA methylation risk scores on bipolar disorder diagnosis. BIPOLAR DISORDERS, 2026, 28(1): e70078.