Transcriptomics reveals New Therapeutic Targets for Ovarian Cancer.

BACKGROUND Ovarian cancer (OC) remains the most lethal gynecologic malignancy, primarily due to late-stage diagnosis resulting from nonspecific early symptoms. This study aims to identify novel genetic targets and elucidate the underlying mechanisms driving OC progression by integrating multi-omics datasets.

METHODS We comprehensively analyzed OC datasets from the Gene Expression Omnibus (GEO) database and applied Mendelian randomization (MR) integrating genome-wide association studies (GWAS) and expression quantitative trait locus (eQTL) data to identify OC-associated genes. Cross-analysis revealed genes co-expressed with both disease-relevant and differentially expressed genes (DEGs), followed by pathway and functional enrichment investigations.

RESULTS Sixteen significant genes were identified, including XPR1, SPINT1, NFE2L3, FGFRL1, SLC24A4, CDC42EP3, PAPLN, GRAMD1B, TMEM71, MAP1A, CD36, ADRA2A, MYL9, PPBP, SIGLEC11 and CMTM5. These genes predominantly regulate tumor immune cell activity, with CIBERSORT analysis revealing distinct immune cell distribution patterns in OC.

CONCLUSIONS Our findings provide novel insights into OC molecular mechanisms and highlight promising therapeutic targets, establishing a foundation for future research and clinical applications.