MedicineBiologyEnvironmental Science

Targeting TBK1 With GSK8612 Suppresses Kidney and Cardiac Inflammation and Fibrosis in DOCA/Salt Hypertension

Jiamin Huang, Wei Rong, Ling Li, Wenqiang Yu, Shuangquan Chen, Haihui Xie, Hua Liang

2026.1.1NEPHROLOGY

DOI: 10.1111/nep.70166

Abstract

To investigate the therapeutic potential of GSK8612, a selective TBK1 inhibitor, against the inflammatory and fibrotic pathological remodeling in the heart and kidneys induced by DOCA/salt hypertension in mice.

Citation format

HUANG, Jiamin, et al. Targeting TBK1 with GSK8612 suppresses kidney and cardiac inflammation and fibrosis in doca/salt hypertension. NEPHROLOGY, 2026, 31(1): e70166.