MedicineBiologyEnvironmental Science

Weidong Zhang, Shasha Li, Yajun Cui, Y. Lun, Hongrui Liu, Minqi Li

2026.1.1CNS Neuroscience & Therapeutics

DOI: 10.1002/cns.70754

Abstract

The bidirectional relationship between Alzheimer's disease (AD) and periodontitis highlights a critical interface between oral and brain health, increasingly recognized as a key axis in aging‐related degenerative diseases. This review synthesizes epidemiological, pathological, and mechanistic evidence underpinning their interconnected pathogenesis.

Citation format

ZHANG, Weidong, et al. The interface of oral and brain health: Current insights into the bidirectional relationship between alzheimer's disease and periodontitis. CNS Neuroscience & Therapeutics, 2026, 32(1): e70754.