Medicine

Targeting hORAI1-Mediated Calcium Influx in Triple-Negative Breast Cancer: A Computational Drug Discovery Approach

S. Pandi, H. Nagarajan, S. Subramaniyan, J. Jeyaraman, S. Ranganathan, L. Kulanthaivel

2026.1.29JOURNAL OF MEMBRANE BIOLOGY

DOI: 10.1007/s00232-025-00365-0

tlooto Summary

These findings provide novel insights into the structural gating processes of hORAI1 and emphasize the therapeutic potential of small compounds that target its closed state to inhibit calcium-mediated carcinogenesis in TNBC.

Abstract

Abstract is not available.

Citation format

PANDI, S., et al. Targeting horai1-mediated calcium influx in triple-negative breast cancer: A computational drug discovery approach. JOURNAL OF MEMBRANE BIOLOGY, 2026, 259(1): 4.