Katsunori Arai, H. Tokuyasu, Yuriko Sueda, Hiromitsu Sakai, Hirara Watase, Mikako Yoshioka, Yoshiki Naritomi, Chika Esumi, Akira Yamasaki
2026.1.1Case Reports in Medicine
tlooto Summary
An extremely rare case of MTX‐LPD with peripheral T‐cell lymphoma (PTCL) phenotype and lung and skeletal muscle involvement and Remission was achieved soon after discontinuing MTX.
Abstract
Methotrexate (MTX) can cause MTX‐associated lymphoproliferative disorders (MTX‐LPDs) characterized by a T‐cell phenotype. Herein, we report an extremely rare case of MTX‐LPD with peripheral T‐cell lymphoma (PTCL) phenotype and lung and skeletal muscle involvement. A 66‐year‐old man who had received MTX for 8 years for rheumatoid arthritis was admitted for right groin pain. A computed tomography scan revealed masses in the right middle lobe and right psoas muscle and multiple nodules in both lung fields. Pathological and immunohistochemical examinations of a lung nodule and psoas muscle tumor revealed PTCL. Remission was achieved soon after discontinuing MTX.
Citation format
ARAI, Katsunori, et al. Methotrexate‐associated lymphoproliferative disorders characterized by a t‐cell phenotype with lung and psoas involvement: A case report. Case Reports in Medicine, 2026, 2026(1): 7668419.