Clinical effect evaluation of interventional embolization combined with pingyangmycin injection in the treatment of trunk and limbs Kaposi type hemangioendothelioma.

OBJECTIVE To evaluate the clinical efficacy of interventional embolization combined with Pingyangmycin injection in children with Kasai-type hemangioendothelioma (KHE).

METHODS A retrospective analysis was conducted on 60 children with KHE admitted between January 2015 and December 2024. All patients were treated with interventional embolization combined with Pingyangmycin injection. Demographic and clinical data of patients were collected. The platelet count, coagulation function, therapeutic effect, and health-related quality of life (HRQoL) scores were compared before and after treatment. Survival outcomes were analyzed using Kaplan-Meier method. Factors affecting HRQoL were analyzed using univariate and multivariate regression analysis.

RESULTS The total effective rate was 80%. The 1-year and 3-year survival rates were 93.3% and 66.67%, respectively. After treatment, the platelet count was significantly increased, and the coagulation function was significantly improved (P<0.05). In addition, the HRQoL scores of each dimension were significantly improved after treatment (P<0.01). Univariate and multivariate analysis identified activity disorder, platelet count, and parents' education level as independent factors affecting HRQoL (all P<0.05).

CONCLUSION Interventional embolization combined with Pingyangmycin injection is an effective method for the treatment of KHE involving the trunk and limbs in children. It demonstrates good effects on correcting thrombocytopenia and improving the quality of life of affected children.