DCC-mediated [3 + 2] annulation between arylisothiocyanate and thioglycolic acid to access N-phenyl rhodanines

Abstract A highly efficient and straightforward [3 + 2] annulation reaction between arylisothiocyanate and thioglycolic acid to facilitated a diverse array of N-phenyl rhodanines by using N,N’-dicyclohexylcarbodiimide (DCC) has been explored. The primarily role of DCC is to activate thioglycolic acid which simplify [3 + 2] annulation reaction. Notably, the advantages of the present methodology included availability of starting material, ease of operation, mild reaction condition, and acceptable yield. Graphical abstract