Pranav Dorwal, Julie Robin, B. Krause, Patricia Pyrchla, Bin Yuan, Robert Quach, Anna Fong Na Goh, Pamela Htain, Noel Djitro, Amit Kumar, Liyan Song, P. Siswara, S. Svobodova, P. Kaub, Beena Kumar
tlooto Summary
It is demonstrated that an RNA fusion panel can be enhanced to identify small nucleotide variants to maximise the utility of this panel.
Abstract
RNA‐based fusion panels using targeted next‐generation sequencing of formalin‐fixed paraffin‐embedded tumour tissue specimens are used for various tumour types to detect rearrangements/fusions. Using bioinformatic approaches, the data obtained from RNA sequencing (RNA‐Seq) can also be used for small nucleotide variants analysis (single nucleotide variants and indels).
Citation format
DORWAL, Pranav, et al. Small nucleotide variant analysis using RNA fusion panel (SMURF): Making the most of rnaseq data in solid tumours. JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2026, 40(4): e70164.