Laura Quintero-Pantoja, Gonzalo Millán-Zambrano
2026.1.1TRENDS IN BIOCHEMICAL SCIENCES
tlooto Summary
It is shown that the nucleotide biosynthetic enzyme phosphoribosyl pyrophosphate synthetase 1 participates in early histone maturation, highlighting a direct molecular link between metabolic state and chromatin assembly.
Abstract
Metabolic enzymes are emerging as key regulators of nuclear processes. A recent study by Srivastava et al. shows that the nucleotide biosynthetic enzyme phosphoribosyl pyrophosphate synthetase 1 participates in early histone maturation, highlighting a direct molecular link between metabolic state and chromatin assembly.
Citation format
QUINTERO-PANTOJA, Laura; MILLÁN-ZAMBRANO, Gonzalo. A metabolic link between DNA synthesis and chromatin assembly. TRENDS IN BIOCHEMICAL SCIENCES, 2026, 51(3): 215–216.