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Insulin Resistance, Anti-inflammatory, and Antioxidant In vitro Activity of Heterologously Expressed Arenin from Dryophytes arenicolor

Enrique Hidalgo-Vázquez, Marilena Antunes-Ricardo, Jesús Hernández-Pérez, Jorge Benavides

2026.1.1Biotechnology Reports

DOI: 10.1016/j.btre.2026.e00947

tlooto Summary

Arenin showed a multifunctional profile, demonstrating its bioactive potential, and induces ROS reduction in HDFA cell line and modulates NO-basal production with LPS in RAW264.7 cell line.

Abstract

Highlights • Arenin increases glucose uptake in the HEPG2 cell line.• Arenin at low doses induces ROS reduction in HDFA cell line.• Arenin modulates NO-basal production with LPS in RAW264.7 cell line.• Arenin showed a multifunctional profile, demonstrating its bioactive potential.

Citation format

HIDALGO-VÁZQUEZ, Enrique, et al. Insulin resistance, anti-inflammatory, and antioxidant in vitro activity of heterologously expressed arenin from dryophytes arenicolor. Biotechnology Reports, 2026, 49: e00947.