Lecithin Provide Alleviation Effect on Impairments of Mitochondrial Adaptations Induced by Pharmacological H1/H2 Blockade

Background: Histamine signaling plays a pivotal role in the post-exercise muscular responses. Blockage of H1/H2 receptor could result in the down-regulation of post-exercise muscle strength. Lecithin is a well-known supplement to improve exercise training effectiveness. In this study, we investigated the effects of lecinthin on H1/H2 antagonists-induced changes in motor performance of mice. Methods: The study was performed on Swiss albino mice brought from Pasteur Institute in Ho Chi Minh City, Vietnam. Mice were divided into 4 groups: Control, lecithin, model and treatment and were underwent a rotarod exercise training procedure. During training processes, mice were given fexofenadine and cimetidine for blocking histamine receptors. Treatment with lecithin were applied during administration of antihistamine drugs. After that, the post-exercise muscle strenght between groups were evaluated via behavioral test including Rotarod Test, Wire Hanging Test and Grip strength test. The changes of biological markers were evaluated in the serum and the muscular tissue of mice via commercial ELISA assay kit. Result: We found that lecithin could ameliorate the detrimental effects of H1/H2 antagonists. In addition, we also revealed the mechanism under this protective effect implicated on the effect of lecithin on mitochondrial adaptation process during exercise training. Administration with antihistamines induced increase in SOD, GPx activity and reduced GSH/GSSG ratio. Treatment with lecithin potentiated this the compensative response of antioxidant enzyme SOD and GPx. Moreover, lecithin also counteracted the effects of antihistamines that decreased GSH/GSSG ratio. In conclusion, our results suggested that lecithin is potentially useful to be taken as a supplement during exercise training and its biological effects, at least in part, related to the regulation of redox balance in muscular tissue during training processes.