Factors Affecting the Time in Therapeutic Range of Warfarin Anticoagulation Therapy in Patients with Atrial Fibrillation

Objective To explore the factors affecting the Time in Therapeutic Range (TTR) of warfarin anticoagulation therapy and propose a novel TTR prediction model. Methods Patients with atrial fibrillation who received warfarin anticoagulation therapy and had complete follow-up data between January 2020 and September 2021 at The First Hospital of Jiujiang City were retrospectively included. All participants were divided into a high quality TTR group and a non high quality TTR group based on whether TTR ≥70%. The predictive value of clinical indicators for TTR was assessed utilizing the area under the receiver operating characteristic curve (AUC). Results A total of 136 patients were included in the final analysis. The results showed that PT, RDW, PDW, RAVD, and NXT were significantly associated with TTR. The combination model of PT, RDW, PDW, RAVD, and NXT resulted in the highest AUC of 0.900 (95% CI: 0.848-0.952) with the specificity (0.835) and sensitivity (0.843). Conclusion PT, RDW, PDW, RAVD, and NXT were important influencing factors for TTR in warfarin anticoagulation therapy. Combining these clinical indicators can effectively predict the TTR of warfarin anticoagulation therapy.