Chemotherapy combined with pembrolizumab in advanced gallbladder cancer with subsequent radical resection: A case report

Gallbladder cancer is often diagnosed at an advanced stage, preventing radical surgical intervention. Combined with its highly aggressive nature, this results in a generally poor prognosis. Although advancements in treatment strategies have expanded the application of conversion therapy for initially unresectable gallbladder cancer cases, achieving eligibility for radical resection remains uncommon. Here, we report a case of advanced gallbladder cancer where treatment with pembrolizumab combined with gemcitabine and cisplatin was followed by successful radical surgical resection, demonstrating a favorable therapeutic outcome. This case highlights the potential of combining immunotherapy and chemotherapy for improving treatment responses and surgical outcomes in advanced gallbladder cancer.