Relationships between the results of lipid profiling, and the levels of matrix metalloproteinases in blood serum in apparently healthy women of different ages

The issues of active longevity are extremely important both for humanity as a whole, and for each individual. There is no unified theory of aging today. Gerontologists agree that aging is caused by many factors that act simultaneously or sequentially. At the same time, most modern theories are based on the study of individual processes occurring during the aging of the body. The aging process alters lipid metabolism by regulating several important pathways involved in lipid transport. In addition, the retention of cholesterol-rich lipoprotein apeS in the artery walls causes several modifications and important biological consequences, including those induced by matrix metalloproteinases (MMPs) which show increased expression with age. The aim of our study was to analyze the values of serum lipid profiling and MMP levels in women of different age, and to assess their interrelations. The study included 157 women, distributed by age (the WHO criteria). The subjects underwent initial medical examination at the clinical bases of the Pacific State Medical University, where the levels of total cholesterol, high-density lipoproteins, low-density lipoproteins, triglycerides, apoliproteins A1, B and MMP values in blood serum were determined. Statistical evaluation of the obtained results was carried out using IBM SPSS Statistics 26 package using nonparametric statistics methods. Results: In conditionally healthy women, depending on age, the total cholesterol levels were high at the age of 45-59 years. In the aged group, this index was significantly reduced. HDL was significantly reduced in the aged group, whereas low-density lipoproteins (LDL) were, on the contrary, increased. The ApoB level was reduced in women under 45 years of age, being increased in the age group of 60-74 years. The ApoB/ApoA1 index was lower in the younger age group compared to women aged 45 years. In conditionally healthy women, MMP-1 values were higher in the middle-aged group. MMP-2 was higher in the middle-aged group, but its highest levels were recorded among the women over 75 years old. MMP-3 did not show any dependence on age. In women over 75 years old, MMP-7 was lower than the values in other age groups. MMP-9 was higher in the group of women aged 45-59 years. According to results of the correlation analysis, conditionally healthy women showed a direct medium-strength relation between the level of ApoB and MMP-2, which correlated with advanced age.