Yat-Ming So, W. H. Kwok, Charlynn Yap, Celia O L Wong, Samuel G R Smalley, Bronte S Forbes, D. Chow, E. Ho
2026.1.18Drug Testing and Analysis
tlooto Summary
Sensitive liquid chromatography tandem mass spectroscopy methods for detecting cyclosporine in horse plasma and urine have been developed and validated, with estimated limits of detection down to 1 pg/mL in both matrices.
Abstract
This paper describes the detection and longitudinal monitoring of cyclosporine in plasma and urine after subconjunctival implant administration in a horse. Sensitive liquid chromatography tandem mass spectroscopy (LC-MS/MS) methods for detecting cyclosporine in horse plasma and urine have been developed and validated, with estimated limits of detection down to 1 pg/mL in both matrices. The developed methods enabled longitudinal monitoring of cyclosporine levels in blood and urine samples collected over 6 months from a horse that had received an ocular cyclosporine implant.
Citation format
SO, Yat-Ming, et al. Detection and longitudinal monitoring of cyclosporine in horse plasma and urine after ocular implant administration. Drug Testing and Analysis, 2026, 18(3): 376–382.