Calorie Restriction: The Elixir of Youth for Kidneys and Testicles?

ÖZ Objective: Reactive oxygen species that accumulate during aging can cause oxidative stress in kidney and testicular tissues, contributing to the progression of chronic kidney disease and to male infertility. Caloric restriction (CR) is considered the most effective non-pharmacological method to promote healthy aging through multiple mechanisms, including modulation of oxidative stress. This study aimed to investigate the effects of short-term CR on kidney and testicular tissues during aging.