Emerging trends in stereoselective glycosyl ester synthesis.

Glycosyl esters constitute a versatile class of molecules with significant roles in medicinal chemistry, natural product synthesis, and materials science. However, achieving their efficient synthesis continues to be a challenge, largely due to difficulties in controlling stereoselectivity and accommodating diverse functional groups. This chapter surveys recent developments in the stereoselective synthesis of glycosyl esters derived from various glycosyl donors. The discussion is organized around key activation strategies, Lewis acid catalysis, organocatalysis, and metal-free methods, highlighting their mechanistic foundations, catalytic efficiencies, and substrate scopes. This chapter aims to serve as a resource for researchers seeking to develop efficient, selective, and environmentally responsible routes to glycosyl esters.