The synergic effect of ultra-micro powder Qiweibaizhusan combined with yeast on dysbacteriotic diarrhea mice

This research aimed to provide scientific basis for preparation development of ultra-micro powder Qiweibaizhusan combined with yeast by exploring its clinic effect on dysbacteriotic diarrhea. First, dysbacteriotic diarrheal mice model was constructed via administration of antibiotics. The modeled mice were treated with 50% amount of ultra-micro Qiweibaizhusan, 50% amount of ultra-micro Qiweibaizhusan + 12.5% amount of yeast, 25% amount of ultra-micro Qiweibaizhusan + 25% amount of yeast, 12.5% amount of ultra-micro Qiweibaizhusan + 50% amount of yeast, and yeast alone, respectively. The body weight, spleen weight, thymus weight, intestinal microbiota and enzyme activities were analyzed. The results showed that the body weight and spleen weight of mice was not influenced by Qiweibaizhusan and yeast. Weight of thymus was promoted by Qiweibaizhusan and yeast ( P > 0.05). Ultra-micro Qiweibaizhusan and yeast could regulate the microecological balance by promoting the growth of Bifidobacterium and Lactobacillus ( P < 0.01). The Escherichia coli and total bacteria amount of the 50% amount ultra-micro Qiweibaizhusan group and the 25% amount ultra-micro decoction + 25% yeast group recovered to the normal level ( P > 0.05). After treatment, the intestinal cellulase enzyme activity recovered to the normal group level ( P > 0.05). The amylase activity of the 50% amount ultra-micro Qiweibaizhusan + 12.5% yeast group and the 25% amount ultra-micro Qiweibaizhusan + 25% yeast group recovered to the normal ( P > 0.05). The activity of xylanase and protease had a certain relationship with the concentration of ultra-micro Qiweibaizhusane and yeast, but did not recover to the normal level ( P < 0.05). Among all ratios, 25% amount ultra-micro Qiweibaizhusan + 25% yeast had the best compatibility and the same effect on