Clinical observation on the efficacy of Shenmai injection in prevention and treatment of neurotoxicity induced by oxaliplatin-containing chemotherapy regimen

OBJECTIVE To study the curative effect of Shenmai injection for prevention of the neurotoxicity caused by chemotherapy drug including oxaliplatin.METHODS The investigation was a prospective study of 96 patients of cancer of stomach and cancer of colon with a need for chemotherapy drug including oxaliplatin.The curative group(46 patients)began to use Shenmai injection(50ml)put in 5%GS one day before chemotherapy,1 time/d,d1-14,ivgtt.So did the control group(50patients),except Shenmai injection.To observe the variation of neurotoxicity and determine nerve peronaeus function after 4 cycles.RESULTS Incidence of neurotoxicity in the curative group was 32.6%(15/46),the other 72.0%(36/50)(P0.05).The curative group was better than the other,which was also supported by nerve peronaeus function(P0.05).that the sensory nerves conduction velocity(SCV)of curative group and control group was(40.5±3.2) m·s-1 and(34.3±3.1) m·s-1 respectively;the action potential amplitude of sensory nerves(9.0±3.8) μV and(7.2±3.3) μV.CONCLUSION It was certained that Shenmai injection was effective in preventing the neurotoxicity caused by chemotherapy drug including oxaliplatin.