A Meta-analysis of ivabradine in treatment of inappropriate sinus tachycardia

Objective To systemic evaluate clinical curative effect of ivabradine in treatment of sinus tachycardia.Methods Through the retrieval of Wanfang database,VIP database,China journal full text database,PubMed,EMBASK database,database SCI/SSCI/AHCI,science direct database,Springer electronic journals and electronic books,the Cochrane Database,all evaluation of Ivabradine for treatment of sinus tachycardia random or non-randomized control trials(retrieval time from state of the database to January 2015),the included studies were evaluated by Jadad quality score,resting heart rate,average heart rate,maximum heart rate,minimal heart rate,daytime heart rale,maximum exercise heart rate were weighted the mean difference(WMD) as the therapeutic index,and the results were analyzed by Rev man 5.2 software.Results A total of 8 studies were included,all were English literature,and the total number of cases was 231,the treatment group with 116 cases,and the control group with 115 cases.Meta-analysis shows that for sinus tachycardia patients,Ivabradine can effectively reduce the resting heart rate(WMD) =-29.55,95%CI-32.69 to-26.41,P 0.01),average heart rate(WMD=-23.41,95%CI-24.81 to-22.00,P 0.01),the maximum heart rate(WMD =-28.69,95%CI-32.03 to-25.34.P 0.01).the minimal heart rale(WMD=-11.42,95%CI-13.86 to- 8.98,P 0.01).the daytime heart rate(WMD =-23.90,95%CI-25.91 to- 21.89,P 0.01),and the maximum exercise heart rate(WMD =-25.20,95%CI-34.40 to- 15.99.P 0.01).Conclusion Ivabradine showed certain curative effect for sinus tachycardia,while its long-term efficacy and safety needed to be confirmed by high quality randomized controlled trials and evidence based medicine.