Relationship Between Plasma Level of Urotensin II and Stability of Coronary Atherosclerotic Plaque in Patients With Acute Coronary Syndrome

Objective:To observe the relationship between the dynamic changes of plasma levels of urotensin Ⅱ(UII)and the stability of coronary atherosclerotic plaque in patients with acute coronary syndrome(ACS).Methods:Our research included 2 groups:ACS group,n=135 consecutive patients treated in our hospital from 2013-03 to2013-08 that including unstable angina pectoris(UAP)sub-group,n=7,non-ST segment elevation myocardial infarction(NSTEMI)sub-group,n=22 and STEMI sub-group,n=106.In addition,there was a Control group,n=48 healthy subjects.Plasma levels of Ull,hs-CRP and NT-proBNP were examined and compared among different groups at different time points.Results:Compared with Control group at immediate admission,ACS group had increased plasma level of UII(39.82±22.28)pg/ml vs(26.88±6.09)pg/ml,P0.001;UII level in STEMI sub-group was lower than NSTEMI sub-group(37.41±22.74)pg/ml vs(48.07±15.82)pg/ml,t=2.092,P0.05.In ACS patients,UII had no correlation to hs-CRP(r=0.041,P=0.639)and NT-proBNP(r=0.112,P=0.261)at immediate admission.There were 58 ACS patients finished the 3months follow-up study and their UII level was increased than immediate admission as(56.52±20.70)pg/ml vs(51.58±18.70)pg/ml,t=-2.366,P0.05.Conclusion:Plasma levels of UII have been changing in different type of ACS patients at immediate admission,UII presented decreasing trend from UAP to NSTEMI to STEMI,while it had increasing trend upon stabilized condition;the admission level of UII had no correlation to inflammatory marker hs-CRP and ventricular overload marker NT-proBNP.UII is not only related to the extent of atherosclerosis,but also related to the nature of atherosclerosis or the stability of plaques.