Molecular and cellular mechanisms of the inhibitory effects of ACE-2/ANG1-7/Mas axis on lung injury.

The beneficial actions of the ANG1-7/Mas pathway are summarized, specifically on lung cells in non-neoplastic lung injury and the currently known downstream signaling mechanisms of the Angiotensin converting enzyme-2 (ACE-2)/ANG1- 7/ Mas pathway in various lung cell types known to be key in acute injury and fibrogenesis are reviewed.