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A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity.

Ilan S. Weisberg, P. Tran, B. Christensen, Sahar Sibani, R. Rozen

1998.7.1MOLECULAR GENETICS AND METABOLISM

DOI: 10.1006/mgme.1998.2714

tlooto Summary

A second common variant in MTHFR (A1298C), an E to A substitution, was characterized, associated with decreased enzyme activity; homozygotes had approximately 60% of control activity in lymphocytes, lower than that seen in single heterozygotes for the C677T variant.

Abstract

Abstract is not available.

Citation format

WEISBERG, Ilan S., et al. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. MOLECULAR GENETICS AND METABOLISM, 1998, 64 3: 169–72.