Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine/nitric oxide area of research.

The present article gives an overview of the currently available assays of nitrite and nitrate in biological fluids based on the Griess reaction, the most frequently used analytical approach to quantitate the major metabolites of NO, i.e. nitriteand nitrate, in a variety of biological fluids, notably blood and urine.