Cancer cell killing via ROS: To increase or decrease, that is the question

The paradox in the rationales of two opposite ROS-manipulation strategies and the concerns for their use are discussed, as well as a combinational set of cellular parameters including redox status, antioxidant enzymes expression, cell signaling and transcription factor activation profiles, namely "redox signaling signature", is waiting for being developed in order to choose ROS-elevating or ROS-depleting therapy specific to certain type of cancer cells.