C. Sirlin, S. Reeder
tlooto Summary
An overview of iron deposition and diseases where liver iron overload is clinically relevant is provided and why quantitative non-invasive biomarkers of liver iron would be beneficial is reviewed.
Abstract
Iron overload is the histological hallmark of genetic hemochromatosis and transfusional hemosiderosis but also may occur in chronic hepatopathies. This article provides an overview of iron deposition and diseases where liver iron overload is clinically relevant. Next, this article reviews why quantitative non-invasive biomarkers of liver iron would be beneficial. Finally, we describe current state of the art methods for quantifying iron with MRI and review remaining challenges and unsolved problems,
Citation format
SIRLIN, C.; REEDER, S. Magnetic resonance imaging quantification of liver iron. Magnetic Resonance Imaging Clinics of North America, 2010, 18: 359-ix.