Open AccessMedicineBiology

HIF-1: upstream and downstream of cancer metabolism.

G. Semenza

2010.2.1CURRENT OPINION IN GENETICS & DEVELOPMENT

DOI: 10.1016/j.gde.2009.10.009

tlooto Summary

Many metabolic abnormalities in cancer cells increase HIF-1 activity, and a feed-forward mechanism can be activated that drives Hif-1 activation and may promote tumor progression.

Abstract

Abstract is not available.

Citation format

SEMENZA, G. HIF-1: Upstream and downstream of cancer metabolism. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2010, 20 1: 51–6.