Clinical applications of GnRH agonist deslorelin in dogs and cats.

The potent GnRH agonist deslorelin, formulated in a low dose, slow-release implant, is commercially available in many countries and its use is increasingly becoming more common in small animal reproduction practice. Although approved only for long-acting reversible contraception and in the control of androgen-related disorders in male dogs, deslorelin (Suprelorin®) has been used off-label in various aspects. The benefits in clinical practice are due to both the flare effect (immediate response) and down-regulation (chronic response) of GnRH receptors. Based on research and clinical data published recently, the clinical applications in dogs and cats include contraception, oestrous induction, management of benign prostatic hyperplasia, treatment of post-spays urinary incontinence and treatment of sex hormone-related behavioral problems.