Role of the liver in the control of carbohydrate and lipid homeostasis.

The present review will focus on some of the genetically-altered mouse models that have helped identify enzymes or transcription factors that are essential for maintaining either glucose or lipid homeostasis in liver and discuss transgenic mice overexpressing key gluconeogenic enzymes (PEPCK, G6Pase), transcription factors (Foxo1, Pgc1-alpha) that control de novo glucose synthesis.