Open AccessBiologyMedicine

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.

R. McBeath, Dana M. Pirone, C. Nelson, Kiran Bhadriraju, Christopher S. Chen

2004.4.1DEVELOPMENTAL CELL

DOI: 10.1016/s1534-5807(04)00075-9

tlooto Summary

It is demonstrated that cell shape regulates commitment of human mesenchymal stem cells to adipocyte or osteoblast fate and mechanical cues experienced in developmental and adult contexts, embodied by cell shape, cytoskeletal tension, and RhoA signaling, are integral to the commitment of stem cell fate.

Abstract

Abstract is not available.

Citation format

MCBEATH, R., et al. Cell shape, cytoskeletal tension, and rhoa regulate stem cell lineage commitment. DEVELOPMENTAL CELL, 2004, 6 4: 483–95.