Jianzhao Liu, Y. Yue, Dali Han, Xiao Wang, Ye Fu, Liang Zhang, G. Jia, Miao Yu, Zhike Lu, X. Deng, Qing Dai, Weizhong Chen, Chuan He
2013.12.6Nature Chemical Biology
tlooto Summary
It is reported here that human METTL14 catalyzes m6A RNA methylation, and together with METTL3, the only previously known m 6A methyltransferase, these two proteins form a stable heterodimer core complex ofMETTL3-14 that functions in cellular m6 a deposition on mammalian nuclear RNAs.
Abstract
N6-methyladenosine (m6A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m6A RNA methylation. Together with METTL3, the only previously known m6A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-14 that functions in cellular m6A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.
Citation format
LIU, Jianzhao, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA n6-adenosine methylation. Nature Chemical Biology, 2013, 10: 93–95.