Influence of molecular and chemical chaperones on protein folding.

It is discussed how a number of different low molecular weight compounds, all known to stabilize proteins in their native conformation, are effective in rescuing the processing defect of the mutant cystic fibrosis transmembrane conductance regulator protein, and how these same compounds, which are now called chemical chaperones, also may prove to be effective in correcting a large number of other protein folding abnormalities.