J. Estrada, G. Martens, Ping Li, A. Adams, K. Newell, M. Ford, James R. Butler, R. Sidner, M. Tector, J. Tector
2015.3.1XENOTRANSPLANTATION
tlooto Summary
To further characterize glycan‐based species incompatibilities, human and non‐human primate antibody binding to cells derived from genetically modified pigs lacking these carbohydrate‐modifying genes was examined.
Abstract
Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2 glycosyltransferase may also synthesize xenoantigens. To further characterize glycan‐based species incompatibilities, we examined human and non‐human primate antibody binding to cells derived from genetically modified pigs lacking these carbohydrate‐modifying genes.
Citation format
ESTRADA, J., et al. Evaluation of human and nonhuman primate antibody binding to pig cells lacking ggta1/cmah/β4galnt2 genes. XENOTRANSPLANTATION, 2015, 22: 194–202.