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MedicineChemistry

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.

Christopher, A. Lipinski, Beryl, W. Dominy, Paul, J. Feeney

2001ADVANCED DRUG DELIVERY REVIEWS

DOI: 10.1016/j.addr.2012.09.019

tlooto Summary

Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described and useful predictions are possible in closely related analog series when coupled with experimental thermodynamicsolubility measurements.

Abstract

Abstract is not available.

Citation format

CHRISTOPHER, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. ADVANCED DRUG DELIVERY REVIEWS, 2001, 46 1-3: 3–26.