tlooto
Sign up
Open AccessMedicineBiology

Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases.

Y. Sasaki, M. Sakai, S. Miyazaki, S. Higuma, A. Shiozaki, S. Saito

2004.5.1MOLECULAR HUMAN REPRODUCTION

DOI: 10.1093/molehr/gah044

tlooto Summary

It is shown that early human pregnancy decidua contains an abundance of CD4(+)CD25(bright) T cells, which express CD152(CTLA-4) at a high level, and these cells mediate potent inhibition of autologous T-cell proliferation by anti-CD3 stimulation and contribute to the mechanisms mediating maternal immune tolerance of conceptus antigens.

Abstract

Abstract is not available.

Citation format

SASAKI, Y., et al. Decidual and peripheral blood CD4+CD25+ regulatory t cells in early pregnancy subjects and spontaneous abortion cases. MOLECULAR HUMAN REPRODUCTION, 2004, 10 5: 347–53.