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Lrrk2 pathogenic substitutions in Parkinson's disease

I. Mata, J. Kachergus, Julie P. Taylor, S. Lincoln, J. Aasly, T. Lynch, M. Hulihan, S. A. Cobb, R. Wu, C. Lu, C. Lahoz, Z. Wszolek, M. Farrer

2005.9.20NEUROGENETICS

DOI: 10.1007/s10048-005-0005-1

tlooto Summary

This study identified 26 coding variants, including 15 nonsynonymous amino acid substitutions of which three affect the same codon (R1441C, R 1441G, and R1441H) and seven of these coding changes seem to be pathogenic, as they segregate with disease and were not identified within controls.

Abstract

Abstract is not available.

Citation format

MATA, I., et al. Lrrk2 pathogenic substitutions in parkinson's disease. NEUROGENETICS, 2005, 6: 171–177.