J. Lonsdale, Jeffrey A. Thomas, Mike Salvatore, R. Phillips, E. Lo, Saboor Shad, R. Hasz, Gary Walters, Fernando García, N. Young, B. Foster, Michael Moser, E. Karasik, Bryan M. Gillard, Kimberley D. Ramsey, Susan Sullivan, J. Bridge, Harold Magazine, John Syron, Johnelle Fleming, L. Siminoff, H. Traino, M. Mosavel, Laura K. Barker, S. Jewell, D. Rohrer, D. Maxim, Dana Filkins, P. Harbach, Eddie Cortadillo, Bree D. Berghuis, L. Turner, E. Hudson, Kristin Feenstra, L. Sobin, J. Robb, Phillip Branton, G. Korzeniewski, C. Shive, D. Tabor, L. Qi, K. Groch, S. Nampally, Stephen A. Buia, Angela M. Zimmerman, Anna Smith, R. Burges, Karna L. Robinson, Kimberly M. Valentino, Debra Bradbury, M. Cosentino, Norma Diaz-Mayoral, M. Kennedy, T. Engel, Penelope Williams, Kenyon Erickson, K. Ardlie, W. Winckler, G. Getz, D. DeLuca, D. MacArthur, Manolis Kellis, Alexander Thomson, Taylor R. Young, Ellen T. Gelfand, M. Donovan, Y. Meng, George B. Grant, D. Mash, Yvonne Marcus, Margaret J. Basile, Jun Liu, Jun Zhu, Zhidong Tu, N. Cox, Dan L. Nicolae, E. Gamazon, H. Im, A. Konkashbaev, J. Pritchard, Matthew Stevens, T. Flutre, Xiaoquan Wen, E. Dermitzakis, T. Lappalainen, R. Guigó, Jean Monlong, M. Sammeth, D. Koller, A. Battle, S. Mostafavi, M. McCarthy, Manual Rivas, J. Maller, I. Rusyn, A. Nobel, F. Wright, A. Shabalin, M. Feolo, N. Sharopova, Anne Sturcke, J. Paschal, James M. Anderson, E. Wilder, L. Derr, E. Green, J. Struewing, Gary F. Temple, S. Volpi, Joy T. Boyer, E. Thomson, M. Guyer, C. Ng, Assya Abdallah, Deborah Colantuoni, T. Insel, Susan E. Koester, A. Little, P. Bender, T. Lehner, Yin Yao, C. Compton, J. Vaught, Sherilyn J. Sawyer, N. Lockhart, J. Demchok, H. Moore
2013.5.1NATURE GENETICS
tlooto Summary
The Genotype-Tissue Expression (GTEx) project is described, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.
Abstract
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.
Citation format
LONSDALE, J., et al. The genotype-tissue expression (gtex) project. NATURE GENETICS, 2013, 45: 580–585.