Timir Y. Mehta, Laxman M. Prajapati, B. Mittal, C. Joshi, J. Sheth, D. B. Patel, D. M. Dave, R. Goyal
2009.11.1Indian Journal of Dermatology Venereology & Leprology
tlooto Summary
This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
Abstract
BACKGROUND Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians.
AIM To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
METHODS Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.
RESULTS Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.
CONCLUSION This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
Citation format
MEHTA, Timir Y., et al. Association of HLA-B*1502 allele and carbamazepine-induced stevens-johnson syndrome among indians. Indian Journal of Dermatology Venereology & Leprology, 2009, 75 6: 579–82.