P. Nesargikar, B. Spiller, R. Chavez
tlooto Summary
The historical progress of the understanding of the complement system is charted and a synopsis on the activation pathways and its inherent regulators is provided.
Abstract
Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.
Citation format
NESARGIKAR, P.; SPILLER, B.; CHAVEZ, R. The complement system: History, pathways, cascade and inhibitors. European Journal of Microbiology and Immunology, 2012, 2 2: 103–11.