Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.

Investigation of the gastric myenteric and submucosal plexuses in 150 microm cryosections and 8 microm paraffin sections from five autopsy individuals found alpha-synuclein immunoreactive inclusions were found in neurons of the subMucosal Meissner plexus, whose axons could provide the first link in an uninterrupted series of susceptible neurons that extend from the enteric to the central nervous system.